Facial rhytides are a common problem that often presents for treatment. Laser facial skin resurfacing has become a method of treatment for photoaging and pigmentary conditions. Although ex-cellent results can be obtained by high-energy, pulsed carbon dioxide(CO2) laser, significantly morbidity exists due to the con-siderable thermal damage to the skin. Long-pulsed Er:YAG laser (CO3 laser, Cynosure) combines the performance of a CO2 system with the safety and convenience of an Er:YAG. Yet the CO3 laser is more than the combination of two complementary resurfacing lasers. It brings thermal management to skin resurfacing. The CO3 effect is due to a wide range of pulse durations, up to 20 times longer than those delivered by conventional Er:YAG lasers. With the CO3 laser, the user chooses the correct depth of thermal effect for maximum safety and efficacy. The purpose of this study was to evaluate the results of the CO3 laser in the treatment of facial wrinkles. Forty-three patients, aged between 35 and 70 years, with facial wrinkles, were evaluated. Wrinkle improvement was evaluated by the patient's satisfaction, clinical improvement, and photographic analysis before and after the resurfacing pro-cedure. The long-pulsed Er: YAG laser for facial wrinkles is a safe and effective mode for laser skin resurfacing.